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May 1949


Author Affiliations

From the Department of Biochemistry and Pediatrics, the Jewish Hospital of Brooklyn.

Am J Dis Child. 1949;77(5):576-591. doi:10.1001/archpedi.1949.02030040590002

IN 1946 a paper was presented from this laboratory in which it was shown that vitamin A when administered in aqueous mediums is absorbed more readily than vitamin A administered in oil.1 In the course of these investigations, it was observed that in normal infants the absorption of vitamin A, as measured by the vitamin A tolerance test, tends to be low. Moreover, a review of the literature2 indicated that the percentage of fat in the stool is higher in young children than is normally observed in older children.

These observations suggested to us that a diminished rate of intestinal absorption of fats in general, and more specifically vitamin A in oil, exists in young children. This phenomenon should be even more pronounced in the newborn. For this reason, our studies, in which we compared the intestinal absorption of vitamin A in aqueous dispersion with that of. the

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