[Skip to Navigation]
Case Reports
May 1949


Author Affiliations

From the Department of Dermatology and Syphilology, Hospital of the University of Pennsylvania, Philadelphia, Donald M. Pillsbury, M.D., director and the Children's Hospital, Philadelphia, Joseph Stokes Jr., M.D., director.

Am J Dis Child. 1949;77(5):652-658. doi:10.1001/archpedi.1949.02030040666008

THE SUBJECT of nephropathy in congenital syphilis has received scant attention in the literature. Stokes and associates1 and Jeans and Cooke2 commented on the rarity of the condition in their experience. Lereboullet and LeLong3 in a survey of the literature up to 1930 were able to cite only 15 cases in which renal findings were prominent in syphilitic infants. Herrmann and Marr,4 reviewing the subject of syphilitic nephropathies, in 1935, indicated that those due to congenital syphilis were latent for the most part and infrequently encountered. Recently, Platou and his associates5 reviewed 122 cases of congenital syphilis treated with penicillin. No definite cases of nephropathy were seen, with the possible exception of that of 1 infant who showed edema and hematuria early in the course of penicillin therapy. This child recovered uneventfully, and a diagnosis of syphilitic nephritis was not established.

Hutinel,6 Frank7 and,

Add or change institution