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June 1949

TREATMENT OF INFANTILE CONGENITAL SYPHILIS: Results with Aqueous Penicillin Alone in Sixty Infants Followed for an Average of Two Years After Treatment

Author Affiliations

From the Institute for the Study of Venereal Disease, University of Pennsylvania, with the United States Public Health Service cooperating, and the Penicillin-Syphilis Panel of the Hospital of the University. The Institute, the Departments of Pediatrics, Neurology, Ophthalmology and Dermatology and Syphilology; the Division of Venereal Disease Control, Philadelphia City Department of Public Health, and the Philadelphia General and Pennsylvania Hospitals and Children's Hospital are represented in the authorship.

Am J Dis Child. 1949;77(6):729-735. doi:10.1001/archpedi.1949.02030040744003

IN THE treatment of the infant with congenital syphilis, general experience to date has proved penicillin the most satisfactory therapeutic agent. Long term follow-up reports, however, have been lacking, and it is for this reason that our study, based on results in 60 infants1 followed over an average of two years, is presented. Previously, seemingly adequate antisyphilitic therapy in infancy has been followed by late relapses, the development of paresis or interstitial keratitis.

A previous report2 discussed selection of cases, dosages, reactions, complications, deaths and immediate response to treatment. This report concerns itself more with long term observation of whether or not clinical or serologic relapses may take place in spite of initial clinical improvement and whether or not any other complications or sequelae of congenital syphilis may occur.

RESULTS OF TREATMENT  Table 1 shows an analysis of the age at onset of therapy in the 55 patients

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