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Progress in Pediatrics
July 1949

PRESENT TREATMENT OF INFLUENZAL MENINGITISReview of Literature and Report on Twenty-Two Patients Treated with Streptomycin and Sulfadiazine

Am J Dis Child. 1949;78(1):97-117. doi:10.1001/archpedi.1949.02030050106011

IN EVALUATING the results obtained from the treatment of Hemophilus influenzae meningitis with streptomycin, we should like to review the literature, as well as report on a series of 22 patients treated by us in the last two years.

While there are several types of influenzal bacilli, beginning with type A up to type F, which affect the meninges in young children, the bacillus H. influenzae is the outstanding causative agent of this disease and is demonstrated in approximately 90 per cent of patients treated.

The bacterial diagnosis of H. influenzae can be made by staining by Gram's method the sedimented spinal fluid, in which the organism found is an extremely pleomorphic gram-negative rod. It may also be filamentous at times. It can be grown easily on fresh chocolate blood agar. An outstanding feature of the growth of hemophilus bacilli is the satellite phenomenon. When H. influenzae and staphylococci are