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August 1949

DISSEMINATED VISCERAL LESIONS ASSOCIATED WITH EXTREME EOSINOPHILIA: Pathologic and Clinical Observations on a Syndrome of Young Children

Author Affiliations

From the Department of Pathology and the Anemia Clinic, Children's Hospital of Michigan, and the Department of Pathology, Wayne University College of Medicine.

Am J Dis Child. 1949;78(2):153-181. doi:10.1001/archpedi.1949.02030050164002

AMONG the conditions associated with pronounced and persistent - eosinophilia of the blood there is an obscure group of disorders reported under various names, such as chronic eosinophilia,1 eosinophilia leukemoides,2 extreme eosinophilia and leukocytosis,3 eosinophilia and splenomegaly,4 Loeffler's syndrome5 and others. Many cases of so-called eosinophilic leukemia and some instances of familial eosinophilia6 evidently belong in the same ill defined category. Clearcut criteria for a clinical syndrome embracing the entire group have not been established, and few pathologic studies of pertinent cases are available. The diagnosis is, therefore, often difficult.

Prompted by a chance observation made in the course of an autopsy, we studied biopsy specimens of liver obtained from 3 patients with excessive eosinophilia and observed a characteristic widespread lesion which seems to us to represent the anatomic substrate of a clinical entity. We present the pathologic findings, together with clinical observations and with

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