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August 1949

STREPTOMYCIN IN TREATMENT OF WHOOPING COUGH

Author Affiliations

NEW YORK
From the Willard Parker Hospital, Department of Hospitals.

Am J Dis Child. 1949;78(2):201-211. doi:10.1001/archpedi.1949.02030050212004
Abstract

THE ESSENTIAL procedures in the treatment of whooping cough, which included the use of human hyperimmune serums, were discussed in previous papers.1 It has been shown that Hemophilus pertussis, the etiologic agent of whooping cough, is sensitive to streptomycin in concentrations of from 1 to 3 micrograms in a cubic centimeter of medium and, therefore, the antibiotic substance might have some therapeutic value. Bradford and Day2 showed that streptomycin favorably altered the course of murine pertussis. The present report deals with the observations on the effect of streptomycin in children ill with whooping cough treated at the Willard Parker Hospital.

MATERIAL AND PROCEDURES  Streptomycin was administered to 129 patients over a six month period, from April 1 through Sept. 30, 1947. One hundred of these were under 1 year of age. There were an additional 21 children under 1 year who received no streptomycin (table 1).The patients

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