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September 1949


Am J Dis Child. 1949;78(3):302-305. doi:10.1001/archpedi.1949.02030050315002

PSEUDOREACTIONS to tuberculin may cause undue anxiety, unwarranted treatment and expense and psychologic harm. The nature, frequency and characteristics of such pseudoreactions to the Mantoux test have been discussed in a previous publication.1

Pseudoreactions to the tuberculin patch test are a rarity. None were encountered during the experimental period in which old tuberculin from the New York Department of Health was used. They occurred occasionally when the concentration of tuberculin was increased to four times that of standard old tuberculin. For a short period during the war, their frequency increased so conspicuously that an investigation of their origin became imperative. A long search into all eventualities finally revealed the probable cause. A few batches of tuberculin had been concentrated at temperatures between 50 and 60 C. (122 to 140 F.) instead of at 100 C. (212 F.). Resumption of the conventional method of tuberculin concentration, at 100 C., made

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