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September 1949

CHOREA (SYDENHAM): A Study of Fifty-Eight Additional Patients

Author Affiliations

From the Kunstadter Laboratories for Pediatric Research, the Medical Research Institute of Michael Reese Hospital, the Herrick House for Rheumatic Fever and the Department of Pediatrics, University of Illinois College of Medicine.

Am J Dis Child. 1949;78(3):306-313. doi:10.1001/archpedi.1949.02030050319003

IN A STUDY of 107 patients with chorea (Sydenham), one of us (B. M. K.) and Mirman1 observed that chorea with an increased erythrocyte sedimentation rate was in most instances associated with active rheumatic fever. Patients who (in the absence of cardiac failure) had a normal erythrocyte sedimentation rate during the early part of their chorea had no symptoms or signs of rheumatic disease at that time or at any time during a long follow-up period. In that study 15 such patients were followed for five to fifteen years and 14 were followed for one to five years (29 patients for an average of five years), and none of these showed any evidence of rheumatic disease at any time. A review of the literature was included in that study.

In this report, the results of a study of 58 additional patients with chorea are presented. This study is significantly