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September 1949


Author Affiliations

From the Department of Epidemiology, Harvard School of Public Health.

Am J Dis Child. 1949;78(3):324-333. doi:10.1001/archpedi.1949.02030050337006

ONLY recently and in few accounts have clinical and epidemiologic observations concerning mumps meningoencephalitis been confirmed by adequate diagnostic evidence from the laboratory, in spite of general recognition that clinical manifestations are not always pathognomonic. Kane and Enders1 were the first to use serologic methods in a comprehensive study of the disease, and Henle and McDougall2 demonstrated the ease of virus isolation. In the present study of 25 patients with mumps meningoencephalitis, 13 with no enlargement of the salivary glands, conclusions were based on cases diagnosed by means of a combination of the newer technics of serologic study3 and virus isolation.4 These methods provide important tools for a closer understanding of the biologic aspects of mumps infections. The patients presented were followed in two Boston hospitals5 in 1948, a year particularly suited to the study because of the unusual prevalence of mumps in Massachusetts.


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