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September 1949


Author Affiliations

From the Children's Hospital Research Foundation and the Department of Pediatrics, University of Cincinnati College of Medicine.

Am J Dis Child. 1949;78(3):334-348. doi:10.1001/archpedi.1949.02030050347007

GREGG1 reported in 1941 a series of 78 cases of congenital cataract and other congenital anomalies in children whose mothers gave a history of rubella in early pregnancy. Numerous reports and surveys2 have confirmed Gregg's theory of a causal relationship between this maternal infection and the anomalies of the child. Gregg's basic discovery has led to a number of secondary questions which have not yet been answered satisfactorily.

In the first publications, Gregg pointed out that in Australia the rubella epidemic of 1940 which had affected the mothers of children with cataract and other anomalies was of unusual severity and was accompanied with complications rare in the course of ordinary "German measles." He was so impressed by the swelling of the glands of the neck, the sore throat, the involvement of the wrist and ankle joints and the general constitutional disturbance observed in that epidemic that he expressed

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