HUMAN immune globulin, U.S.P. (gamma globulin) is present in fraction II of pooled human plasma.1 Its concentration of antibodies is stated to be approximately twenty-five times the concentration of antibodies in pooled normal adult plasma.2 Human immune globulin has been shown capable of preventing or attenuating measles.3 While ordinary human immune globulin is ineffective in protecting exposed susceptible persons against mumps,2b human immune globulin derived from mumps convalescent serum has been reported to reduce the incidence of orchitis in United States Army personnel with mumps to 7.8 per cent.4 In patients treated without human immune globulin or with ordinary human immune globulin, the incidence of orchitis approximated 27 to 33 per cent.
Human immune globulin has also been shown effective in passive immunization against infectious hepatitis,5 although there is thus far no
(Footnote continued on next page) conclusive evidence of its value in treatment
SILVER FF. TREATMENT OF SCARLET FEVER WITH HUMAN IMMUNE GLOBULIN. Am J Dis Child. 1949;78(3):437–448. doi:10.1001/archpedi.1949.02030050450016