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November 1949


Author Affiliations

From the Department of Internal Medicine, Marquette University School of Medicine, and the South View Isolation Hospital.

Am J Dis Child. 1949;78(5):677-685. doi:10.1001/archpedi.1949.02030050694004

In THE study of any disease, periodic analysis of past experience is always of value in determining the adequacy of current trends in prophylaxis and treatment. Such an analysis in the case of whooping cough leads directly to the controversial question of when prophylaxis should be attempted. In 1944, Fox and Knott1 reported the mortality occurring at the South View Isolation Hospital in Milwaukee and emphasized the importance of early active immunization. In this paper we shall analyze the statistics from this hospital for the past sixteen years to support further our contention that immunization before 6 months of age, while it may not be as successful as that undertaken later, is often necessary as a life-saving measure. Further, we shall review recent studies on early prophylaxis showing that such immunization is clinically successful.

REVIEW OF THE LITERATURE ON PROPHYLAXIS  A brief review of the pertinent literature concerning

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