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November 1949


Am J Dis Child. 1949;78(5):708-716. doi:10.1001/archpedi.1949.02030050725008

THE INFREQUENCY of epidermolysis bullosa in pediatric practice, its occurrence in four members of a family and its presence at birth in a premature infant prompt us to present a paper on this subject. This is a disease of the skin or associated structures, probably of hereditary origin, characterized by the development of vesicles and bullae on a minimum of trauma. The condition was first described by von Hebra in 1870, but not until 1886 was the name "epidermolysis bullosa" given. A number of classifications has been set forth in the literature, but three essential types, as listed by Cockayne,1 are most commonly referred to: (1) epidermolysis bullosa simplex (2) epidermolysis bullosa dystrophica, dominant form, and (3) epidermolysis bullosa dystrophica, recessive form.

Epidermolysis bullosa simplex is usually first noted in infancy, with the bullae located on the areas exposed to injury or friction. The degree of trauma that will

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