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February 1950

BRONCHOPULMONARY MYCOSIS: Simultaneous Primary Occurrence in Four Children and Their Mother with Subsequent Healing by Diffuse Miliary Calcification; a Twelve Year Observation

Author Affiliations

From the Department of Pediatrics, Henry Ford Hospital.

Am J Dis Child. 1950;79(2):233-271. doi:10.1001/archpedi.1950.04040010244004

THE IMPORTANCE of fungi as causes of pathologic changes in the lungs associated with acute and chronic respiratory illnesses is generally recognized. Their relation to pulmonary calcification not proved to be tuberculosis is an important and disputed question.1 The fewness of cases of pulmonary mycoses reported in children, especially within family groups, justifies presenting the record of 5 cases of bronchopulmonary mycosis in a single family.

REVIEW OF THE LITERATURE  Bennett,2 in 1840, was the first to investigate and describe pneumonomycoses. Schnyter,3 in 1847, described mold infection in the lungs. In 1855, Virchow4 gave the name pneumonomycosis to the disease. With 3 cases of chronic pulmonary disease Virchow4 demonstrated at postmortem examination Aspergillus fumigatus, which in his opinion was responsible for the pathologic changes.The early interest in the subject is evidenced by the report of Reubold5 in 1854, disproving Berg's6 original observations

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