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March 1950


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Am J Dis Child. 1950;79(3):438-441. doi:10.1001/archpedi.1950.04040010451003

INVESTIGATIONS on the concentration of antibodies in the cerebrospinal fluid in man and in animals have been made previously with varied results.

Hektoen and Carlsson1 found opsonins but no agglutinins or lysins in the cerebrospinal fluid of actively or passively immunized dogs. Becht and Greer2 also failed to demonstrate lysins or agglutinins in the spinal fluid of these animals. Kafka,3 however, found traces of hemolysins and bacterial agglutinins in the cerebrospinal fluid of immunized dogs.

Starkenstein and Zitterbart4 reported that only undiluted spinal fluid agglutinated typhoid bacilli in rabbits, although the serum titer was as high as 1: 10,000. Ransom5 compared the titer for tetanus antitoxin in the serum with that in cerebrospinal fluid of a strongly immunized horse. He observed that the ratio in this animal was 100: 0.4. Freund6 recorded that in 16 rabbits which he had immunized with dead typhoid bacteria

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