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Case Reports
March 1950

BRAIN DAMAGE IN THE CHILD: A Sequela of Maternal Isoimmunization with the B Factor

Author Affiliations

From the Research Department, Letchworth Village, New York State Department of Mental Hygiene.

Am J Dis Child. 1950;79(3):495-503. doi:10.1001/archpedi.1950.04040010508010

THAT incompatibility of the Rh factor between mother and child may result in brain damage in children who survive the acute phase of the disease in the neonatal period is a well established fact. The clinical picture of this sequela is essentially one of mental deficiency, choreoathetosis and extrapyramidal spasticity.1 Pathologically, there is evidence of brain damage, usually most pronounced in regions which are affected in kernicterus, i. e., the subthalamic nuclei and the lenticular bodies.2 More recently, the possibility has been considered that in the absence of Rh incompatibility, erythroblastosis fetalis, jaundice and kernicterus may result occasionally from maternal isoimmunization during pregnancy by the A or B factor.3 Possible neurologic sequelae of this condition have been the object of a few reports,4 but as yet no pathologic description of the brain damage underlying these sequelae is available.

It is the purpose of this report

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