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April 1950

SPINAL FLUID IN ACUTE POLIOMYELITIS: Changes in Total Protein and Cell Counts on Serial Study

Author Affiliations

From the Department of Pediatrics, University of Texas Medical Branch.

Am J Dis Child. 1950;79(4):633-639. doi:10.1001/archpedi.1950.04040010648003

THE RESULTS of serial examinations of the spinal fluid in acute poliomyelitis, rather surprisingly, have not been reported. The need for such a study has been emphasized recently by Andelman and his co-workers1 in their extensive analysis of values for spinal fluid protein in justifying the diagnosis of subclinical poliomyelitis. The opportunity was afforded us to study 142 specimens of spinal fluid from 31 patients with acute poliomyelitis, and the data obtained comprise the basis of this report.

MATERIALS AND METHOD  Originally, the study was directed toward the evaluation of an experimental chemotherapeutic agent which did not influence the course of the disease.2 All patients were in the acute phase of poliomyelitis and were managed identically, whether nonparalytic or paralytic. There were 13 nonparalytic and 18 paralytic patients. The age range was from 9 months to 38 years, with 15 patients less than 8 years of age, 7

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