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May 1950

THROMBOPENIC PURPURA: Report of Four Cases in One Family

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Am J Dis Child. 1950;79(5):820-825. doi:10.1001/archpedi.1950.04040010837004

HEREDITARY thrombopenic purpura has been the subject of considerable controversy. The standard textbooks mention the possibility of such a diathesis without definitely accepting its existence. Quick1 stated:

Although the suggestion has been made that there may be an hereditary or constitutional disposition to the disease (primary thrombocytopenic purpura), a careful study of the literature does not bear this out.

However, Hess2 in 1916 reported 3 cases of purpura from different families who showed low thrombocyte counts and gave a history of purpura in other members of the family. Unfortunately, he gave no laboratory data on the other members of the families.

Glanzmann3 in 1918 reviewed the entire subject of purpura. From his clinical observations and experiments he concluded that there is a hereditary hemorrhagic diathesis which affects both females and males, in contrast to hemophilia. In 1932, Witts4 reported on three families who showed a hereditary

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