STREPTOMYCIN has proved effective in inhibiting the growth of tubercle bacilli in vitro, in animal tuberculosis and in acute exudative, in miliary and in surface lesions of human tuberculosis. It is much less effective in the presence of caseation, in patients whose organisms have developed streptomycin resistance and in tuberculosis of certain organs, such as the brain, bones, lymph nodes and kidneys.1 This raises questions concerning the factors influencing the reaction between the organism and the antibiotic and suggests methods of improving the treatment of tuberculosis by altering these factors.
One of the crucial factors in this reaction is the concentration of the antibiotic. By employment of the aerosol route of administration, extremely high concentrations of streptomycin may be introduced into the lungs without discomfort and without the consequent danger of toxic blood levels. This route of administration has a further advantage in that certain substances may be added
MILLER JB, ABRAMSON HA, RATNER B. AEROSOL STREPTOMYCIN TREATMENT OF ADVANCED PULMONARY TUBERCULOSIS IN CHILDREN. Am J Dis Child. 1950;80(2):207–237. doi:10.1001/archpedi.1950.04040020216002