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Case Reports
October 1950

INFANTILE CORTICAL HYPEROSTOSIS: Report of a Case with Observations at Autopsy

Author Affiliations

From the Child Research Council and the University of Colorado School of Medicine, Department of Pathology.

AMA Am J Dis Child. 1950;80(4):610-620. doi:10.1001/archpedi.1950.04040020622009

Roentgenographic studies, initiated by Roske (1930)1 and augmented by many others, including Caffey (1939; 1945; 1946)2 and Smyth, Potter and Silverman (1946),3 have resulted in the clinical description of a syndrome now known as "infantile cortical hyperostosis."4

This malady has an abrupt onset and runs the initial part of its course during the first few months of infancy. Acute manifestations—fever, anemia, lymphocytosis, increased sedimentation rate of erythrocytes and tender brawny nonhyperemic edema of soft tissues overlying affected bone—subside spontaneously after a few weeks. Roentgenograms of the skeleton made during this period show scattered focal periosteal "reactions," with lamellated thickening of various bones, including the mandible, scapulas, ribs, femurs, tibias and fibulas. Although self limited, the disease is protracted for several months and terminates gradually, with roentgenologic evidence of slow retrogression of osseous changes until involved bones regain their normal contours.

Attempts to determine etiologic factors and to obtain therapeutic responses

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