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December 1950

LIVER STEATOSIS IN UNDERNOURISHED CHILEAN CHILDREN: II. Study on Some Liver Function Tests

Author Affiliations

SANTIAGO, CHILE
From the Hospital de Niños Manuel Arriarán and Cátedras de Pediatría of Prof. A. Baeza Goñi and J. Meneghello, Universidad de Chile.

AMA Am J Dis Child. 1950;80(6):898-904. doi:10.1001/archpedi.1950.04040020913002
Abstract

AFTER it became known that various dietetic modifications could produce fatty infiltration of the liver, several investigators attempted to determine the effect, if any, of the infiltration on liver function. MacLean, Ridout and Best1 found impairment of sulfobromophthalein sodium excretion in 50 per cent of experimental rats with prolonged liver steatosis. McKibbin and co-workers2 demonstrated in dogs with fatty livers an alteration of the phosphatase of the blood, a deficiency in the excretion of sulfobromophthalein sodium, a prolonged prothrombin time and a reduction in the total cholesterol and in the ester ratio. The results of the colloidal gold test remained normal. Li and co-workers,3 also working with dogs, found an impairment in the excretion of bengal rose and a great susceptibility to chronic poisoning with benzene.

In studies on human beings there have also been attempts to correlate fatty infiltration of the liver accompanying various diseases with

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