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August 1911

INFANTILE PARALYSIS: THE MOST PROMISING OUTLOOK FOR IMPROVEMENT IN TREATMENT FROM THE STANDPOINT OF THE PEDIATRICIAN

Am J Dis Child. 1911;II(2):102-106. doi:10.1001/archpedi.1911.04100080039005
Abstract

GENERAL STATEMENTS  We now know that epidemic infantile paralysis is a result of an infective process produced by a specific virus which affects particularly the vessels of the meninges, leading to marked hyperemia, infiltration and inflammation, and to secondary involvement and degeneration of certain of the adjacent nerve-cells and fibers. The disease itself is a self-limited one, terminated by the production within the organism of antibodies to the specific virus. The duration of the acute symptoms may vary from several days to as many weeks, when they may end fatally or in complete recovery, or may be followed by the palsy of one or more muscles, dependent on the site and the extent of the nerve affection. The early paralysis is always of greater extent than the residual palsy, and is due apparently to pressure on nerve trunks by the edema and infiltration of the meninges. It is only after

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