We now know that epidemic infantile paralysis is a result of an infective process produced by a specific virus which affects particularly the vessels of the meninges, leading to marked hyperemia, infiltration and inflammation, and to secondary involvement and degeneration of certain of the adjacent nerve-cells and fibers. The disease itself is a self-limited one, terminated by the production within the organism of antibodies to the specific virus. The duration of the acute symptoms may vary from several days to as many weeks, when they may end fatally or in complete recovery, or may be followed by the palsy of one or more muscles, dependent on the site and the extent of the nerve affection. The early paralysis is always of greater extent than the residual palsy, and is due apparently to pressure on nerve trunks by the edema and infiltration of the meninges. It is only after
KNOX JHM. INFANTILE PARALYSIS: THE MOST PROMISING OUTLOOK FOR IMPROVEMENT IN TREATMENT FROM THE STANDPOINT OF THE PEDIATRICIAN. Am J Dis Child. 1911;II(2):102–106. doi:10.1001/archpedi.1911.04100080039005
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.