In spite of a vast literature our knowledge of the causation of hemorrhage in the new-born is incomplete. The clinical picture varies widely in different cases. The lesions revealed by post-mortem examination are inconstant. Bleeding from the skin, the umbilical cord, the mucous membranes or the viscera — either singly or combined — is the only feature common to all cases.In addition to the general disease which may be the underlying factor in the production of hemorrhage, the ultimate cause of all persistent and uncontrollable bleeding is probably a blood or vascular change. It seems only rational to suppose that the initial bleeding is induced by a vascular lesion. The cause for the persistent hemorrhage is to be sought in some defect of the normal mechanism for the control of bleeding — the clotting of the blood.It is with this phase of the etiology of hemorrhage
SCHLOSS OM, COMMISKEY LJJ. THE ETIOLOGY AND TREATMENT OF THE SO-CALLED HEMORRHAGIC DISEASE OF THE NEW-BORN: WITH REPORT OF CASES. Am J Dis Child. 1912;III(4):216–225. doi:10.1001/archpedi.1912.04100160009002
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