Charpentier's treatise on the various types of hemoglobinuria is so concise and reviews the literature so thoroughly to the date of its publication that it would be futile to go over the details here. He describes paroxysmal hemoglobinuria as follows:
It usually attacks men (women are seldom affected of a pale and sallow complexion, who may or may not have had some specific disease, such as malaria 01 syphilis, or who have a bad family history, in fact, whose vitality is from any cause lowered.
After exposure to cold the patient has rigors and feels ill. Soon after he passes dark colored urine which contains large quantities of hemoglobin but rarely blood corpuscles.
Holt says in the last edition of his book, page 602:
Paroxysmal hemoglobinuria occurs in childhood, although it is an extremely rare condition.
The subject is not mentioned in other American text-books on children's diseases. Pfaundler and