The facts concerning the origin, course and prognosis of the non-pigmented cancer of the retina occurring in children are well known. Wintersteiner's classical monograph, in which he describes 467 cases, has been referred to as a basis of their remarks by authors who have published accounts of individual cases. Wehrli1 believes that retinal hemorrhages are the prime etiologic factor, because he has found rosettes, the centers of which were formed by the smallest vessels. These vessels were fully developed and for the most part degenerated, while their lumen contained remnants of red blood corpuscles surrounded by epithelial-like tumor cells.2 Lindenfeld3 in the study of the normal eyes of the fetus speaks of "granular rosette folds and folds of undifferential cells. From the cells may be derived the similarly arranged cells of retinal glioma." Fuchs'4 description of the pathology and changes voices the generally accepted opinion:
HANSELL HF. A CASE OF BILATERAL GLIOMA OF THE RETINA. Am J Dis Child. 1915;IX(6):485–489. doi:10.1001/archpedi.1915.04100480026003
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