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Stimulated by the discovery of the cutaneous skin test for tuberculosis, numerous observers, notably Wolff-Eisner, Neisser and Meirowsky, attempted to obtain a similar reaction specific for syphilis. These investigators used syphilitic extracts of liver, but their results on the whole were conflicting, owing to the fact that they obtained reactions with normal liver extracts, as well as those with extracts from syphilitic livers. This peculiar reaction toward normal liver extracts in syphilitic individuals, was described by Neisser as the state of "Umstimmung," or allergic reaction. It was not till 1911 that Noguchi, using pure cultures of numerous strains of the pallida grown on solid media and then ground in a mortar, produced the substance known as luetin. By this process Noguchi claimed that not only spirochetes of different ages, but, in addition, the products of their metabolic processes, were obtained, and these factors he considered important in order to produce
BROWN A. THE LUETIN REACTION IN INFANCY. Am J Dis Child. 1913;VI(3):171–173. doi:10.1001/archpedi.1913.04100330029004
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