This investigation was suggested by the accumulating evidence that there may be danger in a restricted dietary even when the latter is entirely satisfactory in total energy value and in the proportion of protein, fat, carbohydrates and essential salts present in it.1 Many of the proprietary infant foods now frankly advertise that they are only partial foods and as such they often prove of value; but not infrequently they form the chief source of nourishment of infants, and medical literature contains numerous records of malnutrition attributed to them. It is of interest to know whether the failure of such a ration to maintain health or to sustain proper growth is due (a) to the character of some of the nutrients, for example, because its proteins can not supply all of the nitrogen requirements of the organism; or (b) to the absence from it of some essential "vitamine" or "growth
WHEELER R, BIESTER A. A STUDY OF THE NUTRITIVE VALUE OF SOME PROPRIETARY INFANT FOODS. Am J Dis Child. 1914;VII(3):169–183. doi:10.1001/archpedi.1914.04100390002001
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