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February 1916


Author Affiliations

Surgeon to the University Hospital PHILADELPHIA

Am J Dis Child. 1916;XI(2):95-102. doi:10.1001/archpedi.1916.04110080012002

The physiology of the cerebrospinal fluid, its origin, secretion and absorption, has been the object of intensive study during recent years.1 The subject has been studied from many angles and by many observers, and the information thus afforded has opened a new vista into the diseases of the central nervous system, in which the cerebrospinal fluid plays an important part. It has been proved conclusively that the cerebrospinal fluid is, for the most part, at least, a secretory product of the choroid plexus. We have found, moreover, that the secretory activity of this gland may be influenced by certain factors, and in the course of our investigations it was found that thyroid extract had a distinctly inhibitory effect on the output of cerebrospinal fluid—a fact which may be of real practical importance in the treatment of conditions in which excessive secretion is the disturbing element. Many theories have been

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