It is to be expected that the excretion of creatin and of creatinin during acute nephritis in the child will show variations from the normal and from the adult normal; for it has been known for several years, through the earlier work of Amberg and Morrill1 and the later investigations of Rose, of Folin, and of Sedgwick, that creatin, an unusual component in the adult, is a normal constituent of children's urine and that the relation between relative muscle mass and creatinin output, which holds for the human organism at and beyond puberty5 breaks down in children at earlier ages. Again, many investigations demonstrate nitrogen retention in cases of nephritis, experimental and pathologic.6 As far as we are aware, however, it has not been determined what occurs in the child under such conditions. There are a few isolated reports7 bearing on the point but they are
CUTTER IS, MORSE M. STUDIES IN THE METABOLISM OF CHILDREN: I. THE EXCRETION OF CREATININ AND OF CREATIN IN ACUTE NEPHRITIS. Am J Dis Child. 1916;XI(5):326–330. doi:10.1001/archpedi.1916.04110110019002
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