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June 1916


Author Affiliations

From the Harriet Lane Home and Department of Pediatrics, Johns Hopkins University.

Am J Dis Child. 1916;XI(6):441-454. doi:10.1001/archpedi.1916.04110120038003

As the result of the studies of von Pirquet and Schick1 serum sickness is regarded as being closely related to anaphylaxis. There are a number of other conditions also in which anaphylaxis has been considered to play an important etiologic rôle. Thus the so-called idiosyncrasies which occur in many people who suffer from urticaria, vomiting and angioneurotic edema after the ingestion of certain foods seem to depend upon an acquired or possibly an inherited hypersensitiveness to the particular protein involved.

It is not inconceivable that as our knowledge of this subject increases, a number of conditions may be shown to be dependent upon anaphylaxis. Meltzer2 has called attention to the similarity between asthma and anaphylaxis, and in 1906 Wolff-Eisner3 suggested that hay fever was due to the action of the pollen protein in hypersensitive people. But it is evident that the majority of instances of the so-called

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