Diabetes insipidus may be divided into two types: (1) primary or idiopathic cases, including those cases in which there is no evident organic basis for the disease, and (2) symptomatic, including those cases in which some organic disease is present in the brain or elsewhere.At the present time three theories as to the etiology of diabetes insipidus are held: (1) that it is due to a lack of ability of the kidneys to concentrate the urine; (2) that a primary polydipsia exists with normal kidney function; (3) that it is a polyuria, purely symptomatic in origin, produced by stimulation of the kidney by many causes, but in some cases by a hypersecretion of the hypophysis.Erich Meyer1 was the first to claim that the condition was due to a lack of ability of the kidney to secrete a concentrated urine. He showed that in normal individuals the
ROSENBLOOM J, PRICE HT. A METABOLISM STUDY OF A CASE OF DIABETES INSIPIDUS. Am J Dis Child. 1916;XII(1):53–60. doi:10.1001/archpedi.1916.04110130056004
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