There are comparatively few data on the creatin-creatinin content of the blood, as it was not until 1914 that a satisfactory method for its determination was devised by Folin.1 At the same time Folin and Denis2 reported the results of a number of determinations in adults with different clinical conditions. They found that the blood content of normal adults averaged a little over 1.1 mg. of creatinin per 100 c.c. They were unable to find any specific creatinin retention, but found an increased retention (over 20 mg.) in some cases of nephritis. About the same time Neubauer,3 in a paper on the use of creatinin as a test of renal function in nephritis, stated that creatinin retention in the blood was very high in some cases of nephritis, reaching 20 mg. per 100 c.c., and that normally it was present in quantities less than 1 mg. per
VEEDER BS, JOHNSTON MR. THE CREATININ AND CREATIN CONTENT OF THE BLOOD OF CHILDREN. Am J Dis Child. 1916;XII(2):136–144. doi:10.1001/archpedi.1916.04110140029004
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