Studies of the glands of internal secretion have shown that the thyroid gland has a very profound effect on the energy metabolism. An overproduction of the active element of the gland increases the irritability of the nervous apparatus and raises the metabolism, while an underproduction reduces the irritability of the nervous system and lowers the metabolism. The former symptoms are shown clinically in exophthalmic goiter and the latter in myxedema and cretinism.1
Magnus-Levy2 established the fact that in exophthalmic goiter the energy requirements were greatly increased, being from 50 to 70 per cent. above the normal, and that in myxedema and cretinism3 the heat production might be as low as 45 to 50 per cent. below the normal. Du Bois4 reported briefly the results of his researches in Professor Lusk's laboratories, in which he studied the diseases of the thyroid gland and obtained similar results to
TALBOT FB. THE ENERGY METABOLISM OF A CRETIN. Am J Dis Child. 1916;XII(2):145–148. doi:10.1001/archpedi.1916.04110140038005
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