RELATION OF LATE TO EARLY SYPHILIS
The division between early and late hereditary syphilis is largely arbitrary, but, in general, the term "late" is applied to those manifestations which are analogous to the tertiary and quarternary symptoms of acquired syphilis. Having the division on such a basis causes the two types to overlap considerably in regard to age. We may have late lesions as early as birth and early lesions as late as 5 or 6 years of age. As to the upper age limit at which manifestations may occur, none has been established. Changes peculiar to hereditary syphilis are found regularly in the third decade and there are some, notably Fournier, who claim to find manifestations with considerable frequency up to the seventh decade.The clinical cause of the development of the late type of lesion, as well as the longer or shorter interval between the manifestations of invasion
JEANS PC. CLINICAL SIGNS AND DIAGNOSIS OF LATE HEREDITARY SYPHILIS. Am J Dis Child. 1916;XII(4):374–386. doi:10.1001/archpedi.1916.04110160043005
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