The letter by Young and Hopkins provides an interesting perspective into the much-needed ongoing conversation regarding the use of genetic testing in clinical practice to evaluate risk for complex diseases. Certainly, the use of an obesity risk-prediction measure based on genetic information is of great clinical interest and promises great utility in identifying high-risk patients. However, although the work of Belsky and colleagues1 is certainly a scientifically sound attempt in that direction, its actual application within the clinical setting raises controversy.
Fernandez JR. Genetic Risk in Childhood Obesity: Implications for Clinical Practice—Reply. JAMA Pediatr. 2013;167(2):196–198. doi:10.1001/2013.jamapediatrics.255
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