In November, 1911, Döhle1 described certain "bodies" within the cytoplasm of the polymorphonuclear leukocytes in blood smears from thirty patients with scarlet fever. In a number of controls similar "bodies" were found in a patient with pneumonia and two patients with malignant neoplasms. As far as he knew these "bodies" had not been described before and to them the term "inclusion bodies" (Leukocytenenschlüsse) was applied. In March, 1912, Kretschmer2 confirmed these findings and considered their presence in scarlet fever of diagnostic value. The latter also found these "bodies" in smears from patients with pneumonia and tuberculosis and two with diphtheria with streptococcus empyema. More recently Nicoll and Williams3 reported a study of fifty-one cases of scarlet fever, finding the "bodies" in forty-five cases. Similar "bodies" were found in three out of twenty-five controls.
The presence of such "bodies" within the polymorphonuclear leukocytes of cases of scarlet fever
KOLMER JA. LEUKOCYTIC "INCLUSION BODIES" WITH SPECIAL REFERENCE TO SCARLET FEVER. Am J Dis Child. 1912;IV(1):1–6. doi:10.1001/archpedi.1912.04100190004001
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