[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.209.104.7. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
July 1912

LEUKOCYTIC "INCLUSION BODIES" WITH SPECIAL REFERENCE TO SCARLET FEVER

Author Affiliations

PHILADELPHIA
From the Laboratory of the Philadelphia Hospital for Contagious Diseases.

Am J Dis Child. 1912;IV(1):1-6. doi:10.1001/archpedi.1912.04100190004001
Abstract

In November, 1911, Döhle1 described certain "bodies" within the cytoplasm of the polymorphonuclear leukocytes in blood smears from thirty patients with scarlet fever. In a number of controls similar "bodies" were found in a patient with pneumonia and two patients with malignant neoplasms. As far as he knew these "bodies" had not been described before and to them the term "inclusion bodies" (Leukocytenenschlüsse) was applied. In March, 1912, Kretschmer2 confirmed these findings and considered their presence in scarlet fever of diagnostic value. The latter also found these "bodies" in smears from patients with pneumonia and tuberculosis and two with diphtheria with streptococcus empyema. More recently Nicoll and Williams3 reported a study of fifty-one cases of scarlet fever, finding the "bodies" in forty-five cases. Similar "bodies" were found in three out of twenty-five controls.

The presence of such "bodies" within the polymorphonuclear leukocytes of cases of scarlet fever

×