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Article
January 1916

NATURE AND QUANTITATIVE DETERMINATION OF THE REDUCING SUBSTANCE IN NORMAL AND PATHOLOGIC CEREBROSPINAL FLUID

Author Affiliations

NEW YORK
From the Children's Wards and the Pathological Laboratory, Bellevue Hospital, New York.

Am J Dis Child. 1916;XI(1):1-10. doi:10.1001/archpedi.1916.04110070004001
Abstract

I. INTRODUCTION  During the past year we have had opportunity to make a series of quantitative determinations of the reducing power of various specimens of normal and pathologic cerebrospinal fluid, and also to carry out certain observations concerning the nature of the reducing substance. The data thus derived serve as the basis of this communication.

II. THE NATURE OF THE REDUCING SUBSTANCE  It is generally assumed that the reducing agent in cerebrospinal fluid is dextrose—the sugar of blood and body fluids. A review of the literature, however, discloses that there has been considerable divergence of opinion. Halliburton,1 whose views are quoted in several current textbooks, concluded that the reducing substance was pyrocatechin or a pyrocatechin derivative. Connall2 states that it is galactose, although he gives no references or experimental data to uphold this view. The observations of Nawratski,3 Zdarek,4 Rossi5 and others, however, indicate that

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