Preceding the development of toxic symptoms in intestinal intoxication1 there is pronounced diarrhea, vomiting and diminished ingestion of fluid, the relative importance of which varies in different cases. In the acute stage of the symptoms the excretion of urine is greatly diminished, and at this time the urine contains albumin and abundant casts.
During the past year investigation of cases of intestinal intoxication has furnished evidence which emphasizes the importance of the loss of fluid and the impaired secretion of urine. In this communication it is proposed to present such evidence and to discuss its significance with special reference to the symptomatology.
I. NONPROTEIN NITROGEN AND UREA OF THE BLOOD
—The nonprotein nitrogen was determined by the method of Gettler and Baker3 except that the final determination was by aeration instead of by distillation. Fiftieth-normal acid and hundredth-normal alkali were used with methyl red as indicator.
SCHLOSS OM. INTESTINAL INTOXICATION IN INFANTS: THE IMPORTANCE OF IMPAIRED RENAL FUNCTION. Am J Dis Child. 1918;XV(3):165–189. doi:10.1001/archpedi.1918.04110210002001
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