With the introduction of simple and harmless methods for the determination of the presence or absence of tuberculous infection, our knowledge of the prevalence of tuberculosis has made immense strides. The work of von Pirquet, Schick, Hamburger, Ghon and many others has taught us that tuberculous infection is common, much more common than we had previously believed; that its incidence in childhood increases as the age of the child advances; that tuberculous infection is by no means synonymous with tuberculous disease. Moreover, we are now in possession of much evidence which proves (1) that the respiratory tract is in a very large percentage of cases the portal of entry; (2) that the bronchial lymph nodes are the seat of tubercles in almost all children who react positively to tuberculin tests; and (3) that the great majority of cases of adult pulmonary tuberculosis probably depend on these very nodes for their
BASS MH. CUTANEOUS AND INTRACUTANEOUS TUBERCULIN TESTS IN INFANTS AND CHILDREN. Am J Dis Child. 1918;XV(5):313–322. doi:10.1001/archpedi.1918.04110230002001
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