The occurrence of a reducing substance in the urine of infants affected with gastro-enteric or nutritional disorders has long been recognized. Grosz1 examined the urine of fifty breast fed infants and the urine of ten reduced Trommer's and Nylander's solutions. In no case did the urine ferment with yeast. Most of the positive results were from infants ill with gastro-enteric disorders. Grosz observed that melituria diminished when tea was substituted for breast milk, and again increased when the diet of breast milk was resumed. He thought that the reducing action of the urine was due to lactose or to a split product of lactose.
Orban2 concluded that the reducing substance which commonly occurs in the urine of infants with gastro-enteric disturbances is lactose. Tests of the feces in such cases showed the absence of lactase, the ferment which splits lactose into glucose and galatose. It is well known
SCHLOSS OM. THE NATURE OF THE REDUCING SUBSTANCE IN THE URINE OF INFANTS WITH NUTRITIONAL DISORDERS. Am J Dis Child. 1921;21(3):211–219. doi:10.1001/archpedi.1921.01910330002001
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