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February 1922


Author Affiliations

From the Department of Pediatrics, the Johns Hopkins University BALTIMORE; From the Department of Pediatrics, Yale University NEW HAVEN, CONN.; BALTIMCRE
From the Laboratory of the Department of Chemical Hygiene, School of Hygiene and Public Health, the Johns Hopkins University.

Am J Dis Child. 1922;23(2):91-106. doi:10.1001/archpedi.1922.01910380002001

For at least two years our attention has been attracted to the possibility of the existence of more than one kind of rickets. That is, under the head of rickets may be included more than one kind of disturbance of the mineral metabolism of the body which manifests itself in a characteristically defective growth and calcification of the bones. The possibility was suggested by a series of clinical observations concerning the association of rickets with other diseases or pathological conditions and certain peculiar manifestations of rickets itself in some children. Inasmuch, however, as the idea of the duality or multiplicity of rickets rested solely on clinical observations which, at most, were only of a suggestive nature, we have never felt justified in presenting it as a definite hypothesis. But, recently, our experiments with the rat have yielded results which strongly suggest that there may be two distinct forms of the

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