In 1918, Frothingham,1 writing on kidney function as affected by the acute infectious diseases, raised the question as to whether patients without apparent renal involvement would show disturbed kidney function if subjected to proper tests. To determine this, something more than clinical observation is necessary, as indicated by Morse,2 in 1922, who, in discussing the correlation of clinical and pathologic findings in nephritis, states his belief that the clinical findings and pathologic anatomy do not agree at all well and that kidney lesions cannot be interpreted in terms of apparent function.
An illustration of this independence of the clinical and pathologic aspect is found in Veil's3 analysis of congenital cystic kidney, by which he demonstrated that the function may remain normal in all respects in this condition.
Reports appear in the literature of the last ten years concerning unusual findings in sick children which might have found
WILCOX HB, LYTTLE JD. KIDNEY FUNCTION IN ACUTE DISEASE. Am J Dis Child. 1923;26(3):195–210. doi:10.1001/archpedi.1923.04120150002001
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