This report concerns a characteristic feature of the blood picture of epidemic encephalitis which, we believe, will prove extremely valuable in diagnosis and prognosis. Limitation of available clinical material and in ability to explain some features of our work have prevented an earlier presentation of the facts. However, the results of a series of animal experiments carried out by one of us1 recently have substantiated the clinical evidence assembled two years ago. Briefly, this evidence can be summarized: The peroxidase test (copper method) of Sato and Sekiya on myeloid leukocytes is negative in an acute case of typical epidemic encephalitis (with lethargy, ophthalmoplegia, and asthenia or fever), but is positive in any other disease, whether of infectious or non-infectious origin. This is true only of the peroxidase test as done by the copper method, which we believe is superior to other peroxidase methods in simplicity, in sensitivity, in constancy
SATO A, YOSHIMATSU S. THE PEROXIDASE REACTION IN EPIDEMIC ENCEPHALITIS: A NEW DIAGNOSTIC AND PROGNOSTIC METHOD. Am J Dis Child. 1925;29(3):301–312. doi:10.1001/archpedi.1925.04120270002001
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