REVIEW OF THE LITERATURE
The use of vaccine therapy in gonorrheal genital infections dates back a considerable period. It was Wright who, as a result of his investigation, first utilized the gonococcus vaccine. With reference to this vaccine, Jarvis1 makes this statement: "Wright's vaccines are microbes, killed by heating at 60 C. for half an hour. The vaccine material consists of intracellular toxins of the bacteria, as the protoplasm has been inactivated by heat."It is apparent that the original idea of Wright was to provoke an antitoxic action, based on the supposition that the gonococcus particularly acted through the secretion it produced.At a later period, Mainini used other vaccines which were heated to 70 C. and then titered by means of a Thomas-Zeiss hematometer. Mauter2 employed aqueous autogenous vaccines heated only to 53 C. He felt that higher temperatures diminish the power of the vaccine. As
BLANCO LV, VILLAZON NM. THE TREATMENT OF GONORRHEAL VULVOVAGINITIS IN INFANTS BY MEANS OF VACCINES. Am J Dis Child. 1926;32(6):805–811. doi:10.1001/archpedi.1926.04130120002001
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