Almost fifty years ago, Mikulicz1 reported before the Verein fur Wissenschaftliche Heilkunde a case of chronic, bilateral, painless enlargement of the salivary and lacrimal glands, for the cause of which he could not advance an adequate explanation, but which he believed to be a low grade infection. Report followed report with great rapidity, so that by 1909 Campbell Howard2 was able to collect reports of eighty-one cases, the clinical characteristics of which corresponded in many ways with those of the one reported by Mikulicz. It had early become evident, however, that although all cases presented the one common feature, i. e., symmetrical enlargement of the lacrimal or salivary glands, they differed widely in many other important particulars. The course in many cases was that of a benign, self-limited condition, whereas in others it was a rapidly fatal one. Pathologically, the material obtained at biopsy or necropsy differed widely
SCHAFFER AJ, JACOBSEN AW. MIKULICZ'S SYNDROME: A REPORT OF TEN CASES. Am J Dis Child. 1927;34(3):327–346. doi:10.1001/archpedi.1927.04130210002001
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