To attract attention to that group of metabolic disturbances that manifests itself by the development of edema without the cardiovascular mechanism necessarily being involved, we are using the term nephrosis. These disturbances are commonly believed to be of renal origin or to be associated with kidney dysfunction of some kind. The fact is well established that cardiovascular disturbances and kidney disease may lead to generalized edema, and the explanation for the occurrence of edema under these circumstances seems quite clear. It is not clear how generalized edema may occur in the absence of primary disease in these systems. It is conceivable that some underlying fault of metabolism may bring about characteristic changes in the kidneys which are not necessarily confined to these organs but which may, on careful search, be shown to involve other structures of the body in a similar way.
We present a study of a case of
COWIE DM, JARVIS KM, COOPERSTOCK M, Nakao A. METABOLISM STUDIES IN NEPHROSIS: WITH SPECIAL REFERENCE TO THE RELATIONSHIP OF PROTEIN INTAKE TO NITROGEN RETENTION, EDEMA AND ALBUMINURIA. Am J Dis Child. 1930;40(3):465–483. doi:https://doi.org/10.1001/archpedi.1930.01940030003001
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