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November 1932


Author Affiliations

From the Hospital of the Rockefeller Institute for Medical Research.

Am J Dis Child. 1932;44(5):921-963. doi:10.1001/archpedi.1932.01950120003001

The precise nature of the leukocytic reactions during measles still remains a subject concerning which there are surprising differences of opinion. Although it is generally held that a leukocytosis is present during the incubation period, followed as a rule by a leukopenia during the acute febrile stage,1 there is a lack of agreement regarding the changes in the differential count. It was early pointed out by several investigators2 that the fall in the blood count was due chiefly to a diminution in the number of lymphocytes. Diametrically opposed to this finding, however, have been the reports of a lymphocytosis occurring simultaneously with the rash.3 Moreover, it has been maintained4 that variations in the number of polymorphonuclear cells principally account for the leukocytosis or the leukopenia observed in the different phases of the disease. More recent workers,5 on the other hand, have laid great stress on

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