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Article
December 1934

TREATMENT OF WHOOPING COUGH WITH AN ACTIVE UNDENATURED ANTIGEN

Author Affiliations

SAN FRANCISCO; BERKELEY, CALIF.
From the Department of Pediatrics, University of California Medical School, San Francisco, and the Department of Bacteriology, University of California, Berkeley, Calif.; Dr. Jacques Gray, Assistant Director of Public Health, San Francisco, furnished the epidemiological data. Dr. Francis Scott Smyth and Dr. Bettie U. Harris also assisted in the preparation of this report.

Am J Dis Child. 1934;48(6):1183-1192. doi:10.1001/archpedi.1934.01960190003001
Abstract

CURRENT EPIDEMIC AND MATERIAL  In a previous communication we reported a preliminary study1 conducted to ascertain the therapeutic value of pertussis antigen prepared according to the method described by Krueger2 and adapted to Haemophilus pertussis by Krueger, Nichols and Frawley.3 The preliminary work included two groups of cases, one observed in Fresno, Calif., by Dr. J. M. Frawley and the other seen in the outpatient clinic of the department of pediatrics of the University of California Medical School by one of us (M. S.). The present report details the complete study on the latter group.The epidemic which we have followed began in December 1932; it was generalized throughout the state of California and was still in progress, although comparatively few cases were developing, at the time of writing (August 1933). The incidence had been 222 reported cases per hundred thousand population. The trend had been from

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