Hypersensitiveness of the skin to products of hemolytic streptococci has been studied by numerous investigators. In most instances the tests have been made with filtrates. With such complex antigens the difficulties in interpreting reactions are obvious. Derrick and Fulton1 have reported on cutaneous reactivity to various bacterial nucleoproteins in patients with a variety of diseases. Ando and Ozaki2 have reported the results of cutaneous tests with nucleoprotein from Streptococcus scarlatinae in a group of 860 patients. The tests to be reported here were performed with purified hemolytic streptococcus nucleoprotein and were carried out on patients with an infection known to be caused by the hemolytic streptococcus, which causes scarlet fever. For controls, 617 children in the wards of the Babies Hospital who did not have scarlet fever, rheumatic fever or nephritis were tested. While these studies were being carried out at the Willard Parker Hospital, Gibson and McGibbon
LYTTLE JD, SEEGAL D, JOST EL. CUTANEOUS REACTIONS TO HEMOLYTIC STREPTOCOCCUS NUCLEOPROTEIN IN PERSONS WITH SCARLET FEVER. Am J Dis Child. 1935;50(3):573–580. doi:10.1001/archpedi.1935.01970090003001
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