In the preceding studies of hypovitaminosis A in children we1 indicated a clinical method of measuring the reflex irritability of the eye to light when both the child and the experimenter are perfectly adapted to darkness. We called this measurable magnitude the minimum reflexible.
Just as it is possible by measuring the degree of hemeralopia in the older child and the adult to demonstrate latent hypovitaminosis A, it is possible by measuring the minimum reflexible of the young child to obtain a quantitative expression for the vitamin A deposited in the organism.
Since we were able to detect a distinctly measurable reduction of the minimum reflexible in a series of children under 1 year of age who had for some time received a diet poor in vitamin A, and since that reduction lessened immediately after a single therapeutic dose of a vitamin A preparation, we think it justifiable to
FRIDERICHSEN C, EDMUND C. STUDIES OF HYPOVITAMINOSIS A: III. CLINICAL EXPERIMENTS IN THE VITAMIN A BALANCE IN CHILDREN AFTER VARIOUS DIETS. Am J Dis Child. 1937;53(5):1179–1201. doi:10.1001/archpedi.1937.04140120003001
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